Which pathways are yours
Tissue-resolved regulatory mapping across your genome. Not a risk percentile — the machinery itself, and therefore what to watch and where.
Lisgen tells you what changed, what is coming, and what actually moves it — calibrated to you rather than to a population average. Your lab calls a 3 kg drop in strength normal variation. For you it may be the first real signal.
01
Standard panel · Population reference
A published minimal detectable change of 5.0 kg is an average across strangers. It cannot tell you whether a 2.7 kg drop is noise for you or the third step of a real decline, because it was never about you.
Lisgen · Your own threshold
Third consecutive decline, slope −0.24 kg per month, 90% interval excluding zero. Your threshold came from your own measurement scatter under a stated protocol — and we widen it when the protocol slips.
02
Tissue-resolved regulatory mapping across your genome. Not a risk percentile — the machinery itself, and therefore what to watch and where.
Organ-specific aging ranked against your own other organs. Accelerated heart aging carries a 250% higher heart-failure risk.
Pace of aging responds in weeks, not years. Across 51 harmonised intervention studies it ranked among the most responsive of 16 clocks — though clocks disagree on some interventions, and we say which.
Real experiments on your own body. Food, sleep, training, medication — your effect with your uncertainty, not a population average.
Pharmacogenomic phenotype from your sequence, the one place genotype legitimately changes a prescribing decision. Never a dose, never a drug name.
Every refusal carries the study that forbids it. Published as a machine-readable resource, so the limits are checkable rather than asserted.
03
Body
Ten instruments with a published minimal detectable change, each tracked against your own scatter. Resistance training carries an all-cause hazard ratio of 0.87; protein at 1.2–1.5 g/kg/d with training adds 0.39 kg lean per 0.1 g increment.
Mind
There is no meaningful population range for mood. Sleep regularity, activity and mobility shift one to four weeks before a downturn becomes obvious. We detect the change against your own pattern and name which of your factors drives it. We never hand you a diagnosis.
04
All-cause mortality; 0.81 cardiovascular, 0.73 neurological
Hip bone density protected against aerobic-only
Per additional 1,000 steps
VO₂max in 8 weeks, beating the alternatives head-to-head
Lean mass per +0.1 g/kg/d
Fewer adverse drug reactions, seven-country trial
05
Trained assessor, standardised posture, three trials both hands, 60s rest. This is what the published figure assumes.
Prompts enforce posture, rest and trial count. Measured as no different from supervised (p = 0.24) — most of the protocol, none of the clinic.
No prompts, but mean of repeated trials on both sides. Aggregation alone lifts reliability above ICC 0.95.
One hand, one attempt, no protocol. The threshold more than doubles — and a system quoting 5.0 here would invent declines that are not there.
Device · Same task, same night
On nocturnal resting heart rate against an ECG criterion: Oura Gen 4 at 1.94% mean error, WHOOP at 8.17%, Polar Grit X at 16.32%. A device whose own error exceeds the change you are looking for cannot carry the claim, so we refuse it rather than quietly averaging it in.
Labs · Biological variation
Every analyte except serum water shows marked individuality. Where the index of individuality is low, a reference range carries almost no information about you — only your own history interprets the result. We use the published within-subject variation to compute what change is real for you.
06
Refuted · GENEROOS randomised trial
A randomised trial took people at the extremes of genetic predisposition through a six-month dietary intervention and found nothing — P = 0.94. Every company selling genotype-based meal plans is selling a result that failed to replicate.
Supported · What sequence is for
What your DNA does is tell us which mechanisms are yours and what to measure. Then we measure it. That is a better product, and it is still standing when someone checks.